Company

Our approach to corporate culture is to develop and encourage a unique creativity we can leverage throughout the process of scientific discovery at KemPharm®.

Who We Are

KemPharm® is a clinical-stage specialty pharmaceutical company engaged in the discovery and development of proprietary prodrugs that are designed to be improved versions of widely prescribed, approved drugs.

What We Do

We employ our Ligand Activated Therapy (LAT™) technology to create prodrugs that are new molecules in order to improve one or more of the attributes of approved drugs, such as susceptibility to abuse, bioavailability and safety. We create these new prodrugs by chemically attaching one or more molecules, or ligands, to an FDA-approved parent drug. When combined with the parent drug, our ligands create prodrugs designed to have improved drug attributes while maintaining efficacy equivalent to the parent drug. Once administered, targeted human metabolic processes, such as those in the GI tract, separate the ligand from the prodrug and release the parent drug, which can then exert its therapeutic effect.

KemPharm® has employed its LAT™ technology to create a diverse pipeline of prodrug therapeutics that target large market opportunities in pain, attention deficit hyperactivity disorder (ADHD) and other central nervous system indications.

KemPharm’s prodrug product candidate pipeline is focused on the high need areas of attention deficit hyperactivity disorder, or ADHD, and stimulant use disorder. KemPharm’s co-lead clinical development candidates for the treatment of ADHD, KP415 and KP484, are both based on a prodrug of d-methylphenidate, but have differing duration/effect profiles. In addition, KemPharm has received FDA approval for APADAZ® , an immediate-release combination product containing benzhydrocodone, a prodrug of hydrocodone, and acetaminophen.